Charles Carroll, of Carrollton, who was the only Catholic signer of the Declaration of Independence, provided a chapel at Tuscarora in 1764. The cemetery, adjoining the church, contains many unmarked graves of the Irish laborers of the C&O canal and B&O Railroad, who fell victim to the cholera epidemics of 1822 and 1832. The marked tombstones bear the names of many prominent families of the time. The families of Thomas, Day, Spalding, Jarboe, and Dutrow appear on the tombstones.